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KMID : 0363420150290010027
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Journal of Korean Oriental Pediatrics
2015 Volume.29 No. 1 p.27 ~ p.43
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Effects of Aurantii Immaturus Fructus (AI) on Atopic Dermatitis (AD) Induced by DNCB in Mice
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Park Jem-Ma
Chai Jung-Won
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Abstract
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Objectives: The purpose of this study was to investigate the effects of AI on AD induced by DNCB in mice. AI has
antiallergic property that is useful in treating allergy-related-diseases, such as asthma, anaphylactic shock, acute
bronchitis and skin diseases, skin pruritus from gastrointestinal diseases. However, AI has not been studied intensively yet regarding anti-inflammatory effect on AD. Therefore, this study was conducted on 2,4-dinitrochlorobezene (DNCB)-induced mice to investigate effects of AI in AD.
Methods: In the experiment, we divided mice into four groups: a normal group (NOR), a control group (CON), an AI spread group (AI spread), and an AI spread and feeding group (AI spread & feeding). Then examined the changes in the body weight, weights of spleen and ear, thickness of dorsum skin and ear skin, clinical aspects on dorsum skin, historical assessments, proliferation of splenocytes in vitro and in vivo, and cytokine (TNF-α, IL-10).
Results: From the experiment, the ear weight of AI spread & feeding group was significantly dropped and the ear thickness of both AI spread and AI spread & feeding were decreased significantly. Dorsum skin thickness was also decreased significantly in both AI spread and AI spread & feeding group. Also, AI treatment improved the symptoms of AD, such as coloration, erythema and desquamation and had a better effect on AI spread & feeding group. In histopathological observation, thickened epidermis, hyperkeratosis, pigmentation, hypergranulosis, parakeratosis were diminished as well in both AI spread and AI spread & feeding group. In vitro, we could observe when AI was increased as proliferation rate of splenocytes were increased, too.
Conclusions: In conclusion, these data suggest that AI can decrease symptoms of AD and show AI can be useful herbal therapy for AD.
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KEYWORD
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Aurantii Immaturus Fructus (AI), 2, 4-dinitrochlorobenzene (DNCB), Atopic dermatitis (AD)
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